Treatment of cryptococcal meningitis with short-course amphotericin B and flucytosine, followed by itraconazole.
نویسندگان
چکیده
Itraconazole is an orally active triazole antifungal drug which has demonstrated a broad spectrum of activity. It is a potent inhibitor of most human fungal pathogens including Crypro,coccus neoformans (Grant and Clissold, 1989). A recent study by Denning et a1 (1989) revealed the usefulness of itraconazole therapy for cryptococcosis. We also experienced the good result of itra,conazole in the treatment of cryptococcal meningitis (Chotmongkol and Jitpimolmard, 1992).
منابع مشابه
Cryptococcal Meningitis Treatment Strategies Affected by the Explosive Cost of Flucytosine in the United States: A Cost-effectiveness Analysis.
BACKGROUND In the United States, cryptococcal meningitis causes approximately 3400 hospitalizations and approximately 330 deaths annually. The US guidelines recommend treatment with amphotericin B plus flucytosine for at least 2 weeks, followed by fluconazole for a minimum of 8 weeks. Due to generic drug manufacturer monopolization, flucytosine currently costs approximately $2000 per day in the...
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We report the first case of Cryptococcus laurentii meningitis and a rare case of Cryptococcus albidus cryptococcaemia in AIDS patients. Both infections were treated with amphotericin B and flucytosine. The C. laurentii meningitis was controlled after 2 weeks of treatment with no evidence of infection 20 months later. The patient with C. albidus cryptococcaemia, despite the amphotericin B/flucyt...
متن کاملCryptococcal meningitis complicating systemic lupus erythematosus: two patients treated with flucytosine and amphotericin B.
Two fatal cases of cryptococcal meningitis complicating adrenocorticosteroid-treated systemic lupus erythermatosus are reported. In one patient who was treated with flucytosine alone, after an initial period of improvement cryptococci resistant to flucytosine were isolated, and subsequent amphotericine B treatment silated, and subsequent amphotericin B treatment did not alter the progress of th...
متن کاملComparative Effectiveness of Induction Therapy for Human Immunodeficiency Virus-Associated Cryptococcal Meningitis: A Network Meta-Analysis
Background. Multiple international treatment guidelines recommend amphotericin-based combination regimens for induction therapy of cryptococcal meningitis. Yet, only 1 trial has reported a mortality benefit for combination amphotericin-flucytosine, and none have reported a mortality benefit for combination amphotericin-fluconazole. Methods. We conducted a Bayesian network meta-analysis to est...
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Two fatal cases of cryptococcal meningitis complicating adrenocorticosteroid-treated systemic lupus erythematosus are reported. In one patient who was treated with flucytosine alone, after an initial period of improvement cryptococci resistant to flucytosine were isolated, and subsequent amphotericin B treatment did not alter the progress of the disease. In the second patient, who received both...
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ورودعنوان ژورنال:
- The Southeast Asian journal of tropical medicine and public health
دوره 24 1 شماره
صفحات -
تاریخ انتشار 1993